Tumor immunity after viral oncolysis
نویسندگان
چکیده
منابع مشابه
Combination of viral oncolysis and tumor-specific immunity to control established tumors.
PURPOSE Advanced-stage cancers are extremely difficult to treat and rarely result in a cure. The application of oncolytic viruses is a potential strategy for controlling advanced-stage cancer because intratumoral (i.t.) injection of an oncolytic virus, such as vaccinia virus, results in tumor cell lysis and subsequent release of tumor antigens into the microenvironment. Furthermore, the viruses...
متن کاملViral oncolysis studies with a metastatic human tumor in chicks.
The fact that many viruses will propagate in, and some will damage, tumor tissue has been demonstrated by many investigators using many experimental systems. Oncotropism and oncolysis have also been studied in clinical experiments. The literature through 1953 has been reviewed by Moore (5). More recent clinical studies include the systemic administration of certain arthropodborne viruses1 and a...
متن کامل(viral transformation/viral-coded antigens/tumor immunity)
Feline sarcoma virus (FeSV) rescued from transformed nonproducer mink or rat cells contains two FeSV-specific antigens (p15 and p12), and the feline oncornavirus-associated cell membrane antigen (FOCMA). All three antigens are helper virus-independent and are encoded by the FeSV genome. FOCMA, pl5, and p12 antigens cochromatograph as phosphorylated molecules of 85,000 molecular weight (pp85), a...
متن کاملImmunological Aspects of Viral Oncolysis
of disciplines were represented including anthropology, psychology, psychiatry, neurology, mathematics, linguistics, and zoology. One of the major topics was the complexity and variability of primate societies which depend on factors such as the breeding season, estrus cycles, and formation of new groups. Another theme was the evolutionary trend in the naturalistic and biological approaches. An...
متن کاملMolecular imaging with bioluminescence and PET reveals viral oncolysis kinetics and tumor viability.
Viral oncolysis, the destruction of cancer cells by replicating virus, is an experimental cancer therapy that continues to be explored. The treatment paradigm for this therapy involves successive waves of lytic replication in cancer cells. At present, monitoring viral titer at sites of replication requires biopsy. However, repeat serial biopsies are not practically feasible for temporal monitor...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1966
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.92.3.792-.1966